I read through snkenjoi's thread on the smallest useful MD ROM and also TascoDLX's Megadrive demo, both of which inspired me to see if I could make some sort of simple game within the 260-byte TMSS limit that still worked on all MD models (note: this is untested on real hardware, but it works on all emulators, even Fusion with the TMSS bios).
The game pretty much plays like a basic Snake clone (collect food to grow bigger, if you hit yourself or the edges of the stage you die). There is no sound in this demo (not enough space

ROM link.
Known issues are that when you get a food piece, a grey 8x8 tile appears in the top-left corner for a split second, and the controls aren't really as responsive as I'd have liked them to be. However, the game is still very playable.
I'll release the source after I comment it fully. If you're really impatient, you could try disassembling it or something. =P
If you seriously want a screenshot before downloading, behold:
